Neuroscience Archives | Synaptek-DLS https://synapteklabs.com/category/neuroscience/ Deep Learning Science Thu, 20 Oct 2022 14:15:57 +0000 en-GB hourly 1 https://wordpress.org/?v=6.7.1 https://synapteklabs.com/wp-content/uploads/2021/04/fav2-50x50.png Neuroscience Archives | Synaptek-DLS https://synapteklabs.com/category/neuroscience/ 32 32 Global Network Modulation https://synapteklabs.com/global-network-modulation/ https://synapteklabs.com/global-network-modulation/#respond Fri, 19 Aug 2022 22:38:59 +0000 https://synapteklabs.com/?p=3671 Five participants diagnosed with severe medically refractory TS underwent bilateral thalamic DBS stereotactic surgery.

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dulation during thalamic stimulation for Tourette syndrome

Abstract and Figures

Background and objectives Deep brain stimulation (DBS) of the thalamus is a promising therapeutic alternative for treating medically refractory Tourette syndrome (TS).

However, few human studies have examined its mechanism of action. Therefore, the networks that mediate the therapeutic effects of thalamic DBS remain poorly understood.

Methods:

Five participants diagnosed with severe medically refractory TS underwent bilateral thalamic DBS stereotactic surgery.

Intraoperative fMRI characterized the blood oxygen level-dependent (BOLD) response evoked by thalamic DBS and determined whether the therapeutic effectiveness of thalamic DBS, as assessed using the Modified Rush Video Rating Scale test, would correlate with evoked BOLD responses in motor and limbic cortical and subcortical regions.

Results:

Our results reveal that thalamic stimulation in TS participants has wide-ranging effects that impact the frontostriatal, limbic, and motor networks.

Thalamic stimulation induced suppression of motor and insula networks correlated with motor tic reduction, while suppression of frontal and parietal networks correlated with vocal tic reduction. These regions mapped closely to major regions of interest (ROI) identified in a nonhuman primate model of TS.

Conclusions:

Overall, these findings suggest that a critical factor in TS treatment should involve modulation of both frontostriatal and motor networks, rather than be treated as a focal disorder of the brain.

Using the novel combination of DBS-evoked tic reduction and fMRI in human subjects, we provide new insights into the basal ganglia-cerebellar-thalamo-cortical network-level mechanisms that influence the effects of thalamic DBS.

Future translational research should identify whether these network changes are cause or effect of TS symptoms.

Intraoperative-fMRI-during-thalamic-HFS-A-Thalamic-HFS-showing-both-significant

Please open and read PDF here – Global_network_modulation_during_thalamic_stimulation

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]]> https://synapteklabs.com/global-network-modulation/feed/ 0 Skills and Expertise https://synapteklabs.com/skills-and-expertise/ https://synapteklabs.com/skills-and-expertise/#respond Tue, 12 Jul 2022 23:24:41 +0000 https://synapteklabs.com/?p=2731 Invited guest lecturer for the RIKEN Brain Science Training Program. Also delivered courses on basal ganglia physiology in health and disease, with a focus on Parkinson’s disease, Tourette syndrome, and deep brain stimulation.

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We Have The Skills and Expertise

Kevin W McCairn Ph.D. Systems Neuroscience & Brain Research. Systems Neuroscience is only but one of Dr. McCarins expertise. Please review his past experience.

Teaching Experience

  • 2012 – 2016. I was an invited guest lecturer for the RIKEN Brain Science Training Program. I delivered courses on basal ganglia physiology in health and disease, with a focus on Parkinson’s disease, Tourette syndrome, and deep brain stimulation.

Awarded Grants

  • 2012 – Decoding Cerebellar Contributions to Tourettism in Nonhuman primates. Grant-in-Aid –for-Scientific- Research (Kakenhi) Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) – JPY 5,000,000
  • 2014 – Decoding Global Networks Underlying Tourette Symptom Subtypes Using PET and Electrophysiological Methodologies. Tourette Syndrome Association – $150,000
  • 2016 – Deconstructing Cerebellar Contributions to Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Treated Monkey” Non-Linear Oscillology Group – JPY 3,000,000
  • 2017 – Multi-Dimensional Analysis of the Limbic Vocal Tic Network and its Modulation via Voltammetry Controlled High-Frequency Deep Brain Stimulation of the Nucleus Accumbens. Tourette Association of America – $ 135,000
  • 2018 – The Role of Phase Amplitude Coupling Through The Cortico-Basal Ganglia-Cerebellar Axis in The Emergence of Akinesia. Non-Linear Oscillology Group – JPY 3,000,000

Commercial Activity

  • SYNAPTEK Deep learning Solutions was created and registered in Japan as a limited liability company, specializing in the use of advanced techniques and analysis for neuroscientific applications in June of 2017.
  • The core business model is based on our Vulcan AI Deep Learning System, an advanced proprietary machine learning monitoring system, capable of qualitatively identifying different behaviors in freely moving animals while integrating that information with real-time acquisition of neural activity.
  • The system can also be used for advanced data analysis to probe complex systems for hidden causal interactions.

ResearchGate

For more about Dr. McCarin please visit his ResearchGate page.

Please visit- https://www.researchgate.net/profile/Kevin-Mccairn

To help Doctor McCarin continue with his work, please consider a gift to his platform at – wtyl.live/GooglePay

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